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How History Affects Pattern Matching Inside The Genome

In a recent Science magazine article, Löytynoja-Goldman showed that all current Multiple Sequence Alignment algorithms – the bread-and-butter algorithm for biologists studying similarities in genes across different species – completely fail to detect independent insertions in the alignment of sequences, and thus, erroneously mismatches regions of evolutionary volatility. In their improved MSA algorithm, PRANK, they use history itself to improve the performance of this basic algorithm. [more...]


definition of bioinformatics at NIH

The NIH has published, in 2000, a definition of bioinformatics which is supposed to be the 'official' one:
- http://www.bisti.nih.gov/CompuBioDef.pdf

I partly disagree with that!! Or at least, I think it is incomplete.

Bioinformatics is not only providing services and tools for scientists and for analyzing data.
It is also a scientific discipline, in which you make an hypothesis, you write down your assumptions, you manage to find a way to demonstrate it, and then you share your results with other scientists and confront with them.