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The European Conference on Computational Biology (ECCB) is the leading European and one of the primary international conferences in computational biology and bioinformatics. The fifth meeting in this series will be held on September 10-13, 2006 in the resort town of Eilat, Israel. The meeting will be held jointly with the 9th Israeli Bioinformatics Symposium. The Deadline for paper submissions is 15th March 2006.